ARA-290 (Cibinetide)
An EPO-derived helix-B surface peptide reference standard (11-mer). Selectively engages the innate-repair receptor complex (βcR) without activating the homodimeric erythropoietic EpoR pathway, providing a useful tool for receptor-subtype discrimination assays, βcR binding studies, and downstream signaling characterization in vitro. 99%+ purity by HPLC & MS.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
ARA-290 (Cibinetide) is an 11-amino acid peptide based on the helix-B surface of erythropoietin (EPO). It selectively engages the innate-repair receptor complex (βcR — the EPO receptor paired with the common β subunit) without triggering classical erythropoietic signaling through the homodimeric EpoR complex, making it a useful tool for receptor-subtype discrimination experiments in vitro.
This receptor selectivity is pharmacologically useful because it allows researchers to probe βcR-specific downstream signaling (JAK2, STAT3, PI3K pathways) independently of erythropoietic EpoR signaling, with no confounding hematopoietic readout. In vitro receptor-binding and functional assay studies have characterized ARA-290's affinity and signaling profile at the βcR complex.
Preclinical cell and animal model studies have employed ARA-290 as a βcR-pathway pharmacological probe in cytokine profiling experiments and corneal nerve fiber density measurement models. These represent laboratory assay systems and structural characterization contexts; all findings are preclinical.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name | ARA-290 (Cibinetide) |
| CAS Number | 1208243-50-8 |
| Molecular Formula | C₃₃H₅₅N₇O₁₁ |
| Molecular Weight | 713.8 g/mol |
| Sequence / Structure | Ile-Glu-Thr-Arg-Pro-Met-Ala-Ala (11-mer; erythropoietin helix-B surface peptide) |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in sterile water or dilute acetic acid |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-058 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- After reconstitution: stable 14–21 days at 4°C; avoid repeated freeze-thaw.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
