VIP (Vasoactive Intestinal Peptide)
A 28-residue pleiotropic neuropeptide produced in intestinal neurons, hypothalamus, and immune cells. Acts at VPAC1 and VPAC2 receptors (also PAC1). Studied in autonomic nervous system research, GI motility, circadian rhythm biology, and immune modulation.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide produced in enteric neurons, hypothalamic suprachiasmatic nucleus (SCN) neurons, immune cells, and various peripheral tissues. It acts as a potent agonist at VPAC1 and VPAC2 receptors (GPCRs of the secretin receptor family), with some activity at PAC1 receptors, stimulating cAMP accumulation and downstream PKA signaling.
In vitro receptor pharmacology research has characterized VIP's binding affinities and signaling properties at VPAC1, VPAC2, and PAC1 receptors, comparing it to related peptides including PACAP-27, PACAP-38, and secretin. Studies have defined the receptor selectivity determinants within VIP's primary sequence using truncated and alanine-scan analogues.
Circadian biology research has used VIP to study its role in SCN pacemaker synchronization, using hypothalamic slice preparations and bioluminescent reporter cell lines to measure effects on PER/CRY protein oscillations and intercellular coupling. GI research has examined VIP's effects on intestinal smooth muscle relaxation, secretion, and enteric nervous system modulation in ex vivo gut preparations.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | VIP (Vasoactive Intestinal Peptide) |
| CAS Number | 37221-79-7 |
| Molecular Formula | C₁₄₇H₂₃₇N₄₃O₄₃S |
| Molecular Weight | 3,326.8 g/mol |
| Sequence / Structure | His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂ |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water or PBS |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-032 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Reconstituted: stable 14 days at 4°C; carrier protein (0.1% BSA) recommended for dilute aliquots.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
