Semax
A synthetic heptapeptide fragment of ACTH(4-10) stabilized by Pro-Gly-Pro extension. Developed at the Institute of Molecular Genetics (Russian Academy of Sciences). Among the most extensively studied nootropic peptides in neurotrophic, neuroprotective, and cognitive research models.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide analogue of the ACTH(4-7) sequence, stabilized against proteolytic degradation by a C-terminal Pro-Gly-Pro extension. It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as part of a program to identify short peptide fragments of ACTH with neuroprotective and neurotrophic activity independent of the hormone's adrenal effects.
In vitro research has characterized Semax's effects on BDNF and NGF expression in neuronal cultures, its influence on the serotonergic and dopaminergic systems in neuronal preparations, and its interactions with NO synthase and antioxidant pathways. It has been used as a tool to study neurotrophic signaling and to compare BDNF-mimetic peptide activity.
Animal model research has investigated Semax in rodent cognitive tests (Morris water maze, radial arm maze), ischemia-reperfusion models of stroke, and chronic stress paradigms. It is frequently compared to Selank as a complementary neuropeptide with a different mechanism — Semax primarily acting via BDNF/TrkB pathways, while Selank shows immunomodulatory and GABAergic activity.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | Semax |
| CAS Number | 80714-61-0 |
| Molecular Formula | C₃₇H₅₁N₉O₁₀S |
| Molecular Weight | 813.92 g/mol |
| Sequence / Structure | Met-Glu-His-Phe-Pro-Gly-Pro |
| Appearance | White lyophilized powder |
| Solubility | Soluble in water or saline |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-009 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Reconstituted solution stable 14–21 days at 4°C.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
