Cerebrolysin
A standardized neuropeptide complex derived from purified porcine brain protein through enzymatic hydrolysis, yielding low-molecular-weight peptides (MW <10 kDa) and free amino acids. Contains fragments with neurotrophic factor-like activity studied in neuroregeneration, neuroplasticity, and neuroprotection research.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
Cerebrolysin is a well-characterized neuropeptide mixture prepared through standardized enzymatic hydrolysis of purified porcine brain proteins. The final product consists of approximately 85% free amino acids and 15% low-molecular-weight peptides (below 10 kDa), with the peptide fraction retaining neurotrophic-factor-like biological activity in cell-based assays.
In vitro research using primary cortical neuron cultures, hippocampal neurons, and neuronal cell lines has characterized cerebrolysin's effects on neurite outgrowth, dendritic branching, BDNF-like signaling, and protection against glutamate-induced excitotoxicity. Studies have examined its interaction with TrkB (BDNF receptor) and p75 neurotrophin receptor signaling pathways.
The peptide complex has been used as a pharmacological tool in rodent models of ischemia, traumatic brain injury, and Alzheimer's disease pathology, where it has been studied for effects on amyloid precursor protein processing, tau phosphorylation, and hippocampal neurogenesis. Researchers frequently use it as a positive control in experiments validating novel neuroprotective compound assays.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | Cerebrolysin |
| CAS Number | N/A (complex mixture) |
| Molecular Formula | Heterogeneous peptide complex |
| Molecular Weight | <10,000 g/mol (component fractions) |
| Sequence / Structure | Heterogeneous; primarily low-MW neuropeptides and amino acids |
| Appearance | Pale yellow lyophilized powder |
| Solubility | Soluble in sterile water or saline |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-033 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Reconstituted: stable 7–14 days at 4°C; the complex nature makes long-term reconstituted storage inadvisable.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
