Selank
A synthetic heptapeptide derived from the endogenous tetrapeptide tuftsin (Thr-Lys-Pro-Arg), extended with Pro-Gly-Pro for metabolic stability. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. Studied in neuropharmacology, anxiety, and cognitive research models.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic analogue of the endogenous tetrapeptide tuftsin, extended at the C-terminus with a Pro-Gly-Pro tripeptide to improve metabolic stability against serum peptidases. It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and has been studied in neuropharmacological research for several decades.
In vitro studies have examined Selank's interactions with neurotrophin signaling pathways, including BDNF expression modulation in neuronal cell cultures. Research has also characterized its effects on GABA-A receptor function, T-cell immune regulation (as a tuftsin analogue), and cytokine expression in immune cell preparations.
Animal model research has investigated Selank's effects on anxiety behavior in rodent models (open field, elevated plus maze), on stress-induced changes in hippocampal gene expression, and on memory consolidation in passive avoidance tasks. Its combination of immune-modulating activity (via tuftsin) and neurotrophic effects make it a pharmacologically distinctive research peptide.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | Selank |
| CAS Number | 129954-34-3 |
| Molecular Formula | C₃₃H₅₇N₁₁O₉ |
| Molecular Weight | 751.87 g/mol |
| Sequence / Structure | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Appearance | White lyophilized powder |
| Solubility | Highly soluble in water |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-008 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Reconstituted solution stable 14–21 days at 4°C.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
