DSIP
A naturally occurring nonapeptide first isolated from rabbit cerebral venous blood during slow-wave sleep. Tryptophan-containing neuropeptide with a unique internal lactam bridge. Studied across circadian rhythm, stress response, neuroendocrine regulation, and antioxidant research models.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide first isolated in 1974 from rabbit cerebral venous blood perfusate during slow-wave sleep induction by low-frequency thalamic stimulation. It contains a unique internal lactam bridge between the Asp5 and Glu9 residues that is essential for its biological activity and contributes to its distinctive conformational properties.
In vitro and animal research has examined DSIP across a range of research areas beyond sleep, including stress response modulation (DSIP reduces plasma ACTH levels in some animal models), free radical scavenging activity, and neuroendocrine regulation involving LH, GH, and cortisol in rodent preparations.
DSIP has also been studied in the context of circadian biology, where it appears to modulate activity-rest rhythms in animal models independently of classic sleep neurotransmitter systems. Its mildly amphipathic nature (water-soluble but with some lipophilic character) and brain-penetrant properties make it a useful tool for central nervous system neuropeptide research.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | DSIP |
| CAS Number | 62568-57-4 |
| Molecular Formula | C₃₅H₄₈N₁₀O₁₅ |
| Molecular Weight | 848.82 g/mol |
| Sequence / Structure | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (with internal lactam Asp5-Glu9) |
| Appearance | White lyophilized powder |
| Solubility | Soluble in water (mildly lipophilic — also dissolves in dilute methanol) |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-012 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Reconstituted solution stable 14–21 days at 4°C; avoid repeated freeze-thaw.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
