Epithalon
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) analogous to Epithalamin, the pineal gland extract studied by Professor Vladimir Khavinson. Among the most investigated peptides in telomere biology, cellular senescence, and epigenetic aging research models.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide based on Epithalamin, a polypeptide fraction isolated from the bovine pineal gland. It was developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology, where it has been studied for over four decades in cellular aging and telomere biology research.
In vitro studies with Epithalon have examined its effects on telomerase activation, telomere elongation in human somatic cells, and the expression of genes associated with cellular senescence. It has been used as a research tool in the study of epigenetic clocks and aging biomarkers in cell culture models.
Animal model studies have investigated Epithalon's influence on pineal gland function, melatonin production, circadian rhythm regulation, and antioxidant enzyme activity. The Khavinson research group has also published extensively on Epithalon's effects in rodent longevity models, though all of these findings remain preclinical.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | Epithalon |
| CAS Number | 307297-39-8 |
| Molecular Formula | C₁₄H₂₂N₄O₁₀ |
| Molecular Weight | 390.34 g/mol |
| Sequence / Structure | Ala-Glu-Asp-Gly |
| Appearance | White lyophilized powder |
| Solubility | Soluble in water (clear solution) |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-010 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Stable at 4°C for up to 30 days after reconstitution.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
