Thymosin Alpha-1
A naturally occurring 28-residue thymic peptide (Tα1) with an N-terminal acetyl group, derived from prothymosin alpha. Studied for modulation of dendritic cell maturation, T-cell differentiation, and toll-like receptor signaling pathways in vitro. A well-characterized immunomodulatory research compound.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
Thymosin alpha-1 (Tα1) is a 28-amino acid peptide with an N-terminal acetyl group, naturally occurring in thymic tissue as a cleavage product of the precursor protein prothymosin alpha. It was first isolated and sequenced in the 1970s and has since been one of the most studied thymic peptides in immunological research.
In vitro research using dendritic cell cultures, T-cell lines, and peripheral blood mononuclear cells has characterized Tα1's effects on differentiation markers, cytokine secretion profiles (IFN-γ, IL-12, IL-10), and TLR signaling pathway activation. It has been used in studies of innate immune priming, Th1/Th2 balance, and regulatory T-cell function.
Cell biology research has examined Tα1's interactions with TLR-2, TLR-9, and associated signaling proteins (MyD88, NF-κB), characterizing the molecular basis for its immunomodulatory activity. It is used as a reference compound in comparative studies of thymic peptides alongside thymosin beta-4, thymulin, and thymalin.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | Thymosin Alpha-1 |
| CAS Number | 62304-98-7 |
| Molecular Formula | C₁₂₉H₂₁₅N₃₃O₅₅ |
| Molecular Weight | 3,108.3 g/mol |
| Sequence / Structure | Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water or PBS |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-023 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Stable at 4°C for 21 days post-reconstitution.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
