KPV
The C-terminal tripeptide (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone (α-MSH), retaining anti-inflammatory signaling activity independent of melanocortin receptor binding. Studied in gut epithelial models, inflammatory signaling pathways, and NF-κB inhibition research.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
KPV (Lys-Pro-Val) is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (α-MSH). While it lacks the N-terminal acetyl group and full-length sequence required for melanocortin receptor binding, KPV retains the anti-inflammatory signaling activity attributed to the C-terminal region of α-MSH.
In vitro research using intestinal epithelial cell lines (Caco-2, HT-29) has examined KPV's effects on pro-inflammatory cytokine secretion (IL-8, TNF-α, IL-6), NF-κB nuclear translocation, and tight junction protein expression. Studies have characterized its ability to enter cells via peptide transporter 1 (PepT1) in the gut epithelium, making it a tool for exploring peptide transport across mucosal barriers.
Cell biology research has examined KPV's interactions with intracellular signaling proteins including IκB kinase and its effects on the NF-κB and MAPK pathways. It is frequently compared to full-length α-MSH in mechanistic studies designed to define which α-MSH activities reside in the C-terminal vs. N-terminal regions of the peptide.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | KPV |
| CAS Number | 65022-50-6 |
| Molecular Formula | C₁₅H₂₉N₅O₄ |
| Molecular Weight | 343.42 g/mol |
| Sequence / Structure | Lys-Pro-Val (C-terminal α-MSH tripeptide) |
| Appearance | White lyophilized powder |
| Solubility | Highly soluble in sterile water |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-025 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Reconstituted solution stable 30 days at 4°C due to small size and high stability.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
