KissPeptin-10
The 10-residue C-terminal amidated fragment of the KISS1 gene product kisspeptin. A potent endogenous agonist of the GPR54 (KISS1R) receptor, which governs hypothalamic GnRH pulse generation and the neuroendocrine control of reproductive axis signaling.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
KissPeptin-10 (Kp-10) is the 10-residue C-terminal amidated fragment of kisspeptin, encoded by the KISS1 gene. It represents the minimal active sequence sufficient for full agonist activity at the kisspeptin receptor (GPR54, also designated KISS1R), a Gq-protein-coupled receptor expressed predominantly in hypothalamic GnRH neurons.
In vitro receptor pharmacology studies have characterized Kp-10's binding affinity, potency, and signaling at GPR54, comparing it to longer kisspeptin isoforms (Kp-13, Kp-54) to define the structural requirements for receptor activation. Cell-based assays using GPR54-transfected HEK293 cells have measured IP3 production, calcium mobilization, and ERK phosphorylation downstream of Kp-10 stimulation.
Neuroendocrine research has employed Kp-10 to characterize the kisspeptin-GnRH signaling axis in hypothalamic slice preparations and primary neuronal cultures, examining effects on GnRH pulse frequency and amplitude. It is used as a pharmacological probe for studying the central regulation of reproductive axis pulsatility and the relationship between kisspeptin neurons and GnRH secretion.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | KissPeptin-10 |
| CAS Number | 374683-26-8 |
| Molecular Formula | C₆₃H₈₃N₁₅O₁₄S |
| Molecular Weight | 1,302.49 g/mol |
| Sequence / Structure | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water or DMSO (1–5%) |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-024 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Reconstituted solution stable 14 days at 4°C.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
