PT-141 (Bremelanotide)
A cyclic heptapeptide melanocortin analogue and metabolite of melanotan II, acting as a potent agonist at melanocortin receptors MC3R and MC4R. Studied in hypothalamic circuits governing arousal, reward processing, and HPA axis signaling. A tool compound in melanocortin system research.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
PT-141 (bremelanotide) is a cyclic heptapeptide analogue derived from the Ac-Nle⁴-c[Asp⁵,D-Phe⁷,Lys¹⁰]-α-MSH(4-10) scaffold (melanotan II core). It acts as a potent full agonist at melanocortin MC1R, MC3R, and MC4R, with particular selectivity for MC4R, which is highly expressed in hypothalamic regions associated with autonomic and neuroendocrine regulation.
In vitro receptor pharmacology studies have characterized PT-141's binding affinity profile across the five melanocortin receptor subtypes (MC1R–MC5R), comparing it to α-MSH, melanotan II, and selective synthetic analogues. Functional assays measuring cAMP accumulation and β-arrestin recruitment have been used to profile its signaling bias at MC3R and MC4R.
Neuroscience research has employed PT-141 to examine melanocortin signaling in hypothalamic circuits, using in vivo microdialysis, neuronal firing recordings, and immediate-early gene expression as endpoints in animal studies. It is also used in PNS models to examine melanocortin effects on peripheral autonomic signaling.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | PT-141 (Bremelanotide) |
| CAS Number | 189691-06-3 |
| Molecular Formula | C₅₀H₆₈N₁₄O₁₀ |
| Molecular Weight | 1,025.16 g/mol |
| Sequence / Structure | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (cyclic) |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-027 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Reconstituted solution: use within 21 days at 4°C.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
