Melanotan II
A synthetic cyclic heptapeptide analogue of α-MSH that acts as a potent non-selective agonist at melanocortin receptors MC1R–MC5R. One of the most widely studied melanocortin research compounds. Used in pigmentation research, melanocortin receptor pharmacology, and neuroendocrine circuit studies.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
Melanotan II is a synthetic cyclic heptapeptide analogue of α-MSH (alpha-melanocyte-stimulating hormone) designed by researchers at the University of Arizona in the 1980s as a more potent and metabolically stable melanocortin agonist. It was one of the first superagonist analogues of α-MSH to be characterized, achieving substantially higher potency at MC1R through the cyclic, D-Phe-containing scaffold.
In vitro receptor pharmacology research has characterized melanotan II's binding affinities and functional agonism across all five melanocortin receptor subtypes (MC1R–MC5R), comparing it to α-MSH, ACTH, and selective analogues. It has been a key tool compound in the pharmacological characterization of the melanocortin receptor family, particularly in studies defining receptor subtype selectivity and signaling pathway engagement.
Pigmentation research has used melanotan II in melanocyte cell cultures to study MC1R-mediated cAMP induction, tyrosinase enzyme activity, and melanin synthesis. Neuroendocrine research has examined its effects on hypothalamic circuits via MC3R and MC4R, including effects on food intake, energy expenditure, and autonomic nervous system activity in rodent models.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | Melanotan II |
| CAS Number | 121062-08-6 |
| Molecular Formula | C₅₀H₆₉N₁₅O₉ |
| Molecular Weight | 1,024.19 g/mol |
| Sequence / Structure | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-028 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Reconstituted solution: stable 14–21 days at 4°C.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
