NAD+
The oxidized form of nicotinamide adenine dinucleotide, a critical coenzyme in cellular metabolism. Central to cellular redox reactions and a substrate for sirtuins, PARPs, and CD38. Among the most researched metabolic compounds in cellular aging and energy metabolism studies.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a fundamental coenzyme present in all living cells and central to hundreds of metabolic redox reactions. It functions as an electron carrier in the mitochondrial electron transport chain and as a substrate for several families of regulatory enzymes including sirtuins (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and CD38 — all of which consume NAD+ in their catalytic cycles.
Research interest in NAD+ has intensified significantly over the past two decades with the discovery that cellular NAD+ levels decline with aging in multiple tissues in both rodent and human studies. In vitro models have examined the effects of NAD+ repletion on mitochondrial function, DNA damage repair (via PARP activation), sirtuin-dependent deacetylation of metabolic enzymes, and cellular stress responses.
Animal studies have investigated NAD+ precursors and direct supplementation in the context of metabolic syndrome models, neurodegeneration, and muscle function. NAD+ itself is used as a research standard and direct-addition substrate in biochemical assays measuring enzyme activity, making pharmaceutical-grade NAD+ an essential laboratory reagent across metabolism and aging research fields.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | NAD+ |
| CAS Number | 53-84-9 |
| Molecular Formula | C₂₁H₂₇N₇O₁₄P₂ |
| Molecular Weight | 663.43 g/mol |
| Sequence / Structure | N/A (dinucleotide coenzyme — not a peptide) |
| Appearance | White to off-white powder |
| Solubility | Freely soluble in water; prepare fresh solutions |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-004 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C, protected from light and moisture. Prepare aqueous solutions fresh; do not store dissolved NAD+.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
