MOTS-c
A 16-residue peptide encoded within the mitochondrial 12S rRNA gene, representing a class of mitochondria-derived peptides (MDPs). Studied for effects on mitochondrial biogenesis, AMPK activation, insulin sensitivity, and metabolic flexibility. An emerging target in aging biology and metabolic research.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
MOTS-c (Mitochondrial ORF within 12S rRNA type-c) is a 16-amino acid peptide encoded by a short open reading frame within the 12S ribosomal RNA gene of the mitochondrial genome. It was first described in 2015 and established a new class of signaling peptides originating from mitochondrial DNA, termed mitochondria-derived peptides (MDPs).
In vitro research has characterized MOTS-c's effects on AMPK activation, folate cycle disruption, and de novo purine synthesis inhibition in cultured cells. These mechanisms are proposed to link mitochondrial metabolic status to nuclear gene expression programs governing glucose utilization, fatty acid oxidation, and antioxidant response.
Skeletal muscle cell research has examined MOTS-c's effects on glucose uptake, fatty acid utilization, and insulin signaling pathway components (AMPK, Akt, GLUT4), while adipocyte studies have explored its effects on lipogenesis and lipolysis. Animal model studies have examined its effects on exercise capacity, age-related metabolic decline, and body composition in aged rodents.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | MOTS-c |
| CAS Number | N/A (novel) |
| Molecular Formula | C₁₀₀H₁₈₁N₃₃O₃₂ |
| Molecular Weight | 2,174.8 g/mol |
| Sequence / Structure | MRWQEMGYIFYPRKLR (16 residues) |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water or PBS |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-019 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Reconstituted solution: use within 7–14 days at 4°C; minimize freeze-thaw cycles.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
