This listing is provided strictly for in vitro laboratory research. It is not a drug, supplement, food, or medical product, is not for human or veterinary use, and has not been evaluated by the FDA. By purchasing you certify that you are at least 21 years of age and a qualified researcher acquiring this material solely for lawful laboratory research.
CL-1SG
A long-acting, fatty-acid-modified incretin receptor agonist peptide. Characterized by a C18 fatty diacid moiety at Lys26 enabling albumin binding, extending plasma half-life in animal models to ~7 days. Widely studied in metabolic research, insulin secretion, and appetite-regulation pathways.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
CL-1SG is a 34-residue incretin receptor agonist peptide characterized for its extended plasma half-life relative to the native incretin peptide. The structural modifications—substitution of Aib at position 8 to resist DPP-IV cleavage, arginine at position 34, and a C18 fatty diacid linker at lysine 26—confer albumin binding and slow subcutaneous absorption in preclinical pharmacokinetic models.
In vitro research using incretin-receptor-transfected cell lines has characterized CL-1SG's receptor binding affinity, cAMP induction, and internalization kinetics. Rodent studies have examined its effects on glucose-stimulated insulin secretion, beta-cell mass, gastric emptying, and hypothalamic appetite circuits.
CL-1SG has served as a reference compound in comparative incretin agonist studies, used alongside shorter-acting analogues to dissect the pharmacodynamic consequences of extended receptor exposure. Researchers have also used it in non-alcoholic steatohepatitis (NASH) models examining hepatic lipid accumulation.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | CL-1SG |
| CAS Number | 910463-68-2 |
| Molecular Formula | C₁₈₇H₂₉₁N₄₅O₅₉ |
| Molecular Weight | 4,113.6 g/mol |
| Sequence / Structure | 34-aa incretin receptor analogue; Aib8, Arg34, C18 FA at K26 |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water or PBS |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-1SG |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Reconstitute in sterile water or bacteriostatic water. Stable 30 days at 4°C post-reconstitution; store lyophilized stock at −20°C.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
