This listing is provided strictly for in vitro laboratory research. It is not a drug, supplement, food, or medical product, is not for human or veterinary use, and has not been evaluated by the FDA. By purchasing you certify that you are at least 21 years of age and a qualified researcher acquiring this material solely for lawful laboratory research.
CL-3RT
A 36-residue synthetic peptide engineered as a triple agonist of the incretin receptor, GIPR, and the glucagon receptor (GCGR). Adding glucagon receptor activity distinguishes it from dual agonists; preclinical models suggest amplified effects on hepatic glucose output and energy expenditure. A frontier compound in multi-receptor metabolic research.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
CL-3RT is a 36-amino acid peptide engineered to activate three incretin and glucagon-related receptors simultaneously: the incretin receptor, GIPR, and the glucagon receptor (GCGR). The addition of GCGR activity distinguishes it from the dual-agonist class, as glucagon receptor stimulation contributes to hepatic glycogenolysis, lipolysis, and increased energy expenditure in animal models.
In vitro receptor binding and functional assays have characterized CL-3RT's agonism at each of the three receptors, examining cAMP response, beta-arrestin recruitment, and receptor selectivity profiles. Researchers have used it as a pharmacological tool to dissect the independent contributions of GCGR vs. incretin receptor activation to changes in hepatic lipid metabolism and adipose tissue energy utilization.
Comparative studies using triple-agonist vs. dual-agonist reference compounds have examined whether GCGR co-activation produces incremental effects on adipose mass, liver fat, and energy balance in rodent obesity models. Structural biology work has included cryo-EM studies of CL-3RT-bound receptor complexes to understand the molecular basis of multi-receptor promiscuity.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | CL-3RT |
| CAS Number | LY3437943 · 2381272-12-2 |
| Molecular Formula | C₂₂₂H₃₄₇N₄₇O₆₈ |
| Molecular Weight | 4,859.5 g/mol |
| Sequence / Structure | 36-aa incretin/GIPR/GCGR triagonist; C20 FA |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water or PBS |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-3RT |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Reconstitute in sterile water. Stable 30 days at 4°C post-reconstitution; lyophilized stock at −20°C.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
