GHK-Cu
A naturally occurring copper-binding tripeptide (Gly-His-Lys) complexed with a copper(II) ion. Found endogenously in human plasma, urine, and saliva. Extensively studied in skin biology, wound healing, and anti-inflammatory in vitro research models.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring tripeptide-copper complex first isolated from human plasma. It is found endogenously in various biological fluids and is thought to play roles in tissue remodeling, wound healing regulation, and antioxidant responses. The copper(II) ion is an integral part of the complex and contributes to its biochemical activity profile.
In vitro research with GHK-Cu has characterized its effects on fibroblast proliferation and contraction, collagen and glycosaminoglycan synthesis, matrix metalloproteinase regulation, and keratinocyte migration in wound healing assays. It has been used extensively as a model peptide to study how copper-containing regulatory molecules modulate extracellular matrix dynamics and skin biology.
Research has also examined GHK-Cu's role as a transcriptional modulator, with microarray and RNA-seq studies suggesting it influences the expression of a broad array of genes involved in tissue repair, immune modulation, and antioxidant defense. These findings have made it a widely referenced compound in both cosmetic chemistry research and fundamental wound biology.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | GHK-Cu |
| CAS Number | 49557-75-7 |
| Molecular Formula | C₁₄H₂₄CuN₆O₄ |
| Molecular Weight | 403.9 g/mol |
| Sequence / Structure | Gly-His-Lys (complexed with Cu²⁺) |
| Appearance | Blue powder (copper complex) |
| Solubility | Soluble in water |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-003 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C, protected from light. Copper complex is stable in aqueous solution; stable at 4°C for up to 30 days post-reconstitution.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
