Snap-8
An 8-residue synthetic peptide analogue of the N-terminal fragment of SNAP-25, a component of the SNARE protein complex. Studied in vitro for effects on neuromuscular junction signaling and SNARE-complex assembly. Used as a reference compound in research examining synaptic vesicle fusion mechanisms.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
Snap-8 (Ac-EEMQRRAD-NH₂) is a synthetic octapeptide derived from the N-terminal region of synaptosomal-associated protein 25 (SNAP-25), a component of the SNARE (soluble NSF attachment protein receptor) complex that mediates synaptic vesicle fusion and neurotransmitter release at the neuromuscular junction.
In vitro biochemical research has characterized Snap-8's interaction with the SNARE complex, examining its ability to compete with endogenous SNAP-25 for ternary SNARE complex formation. Cell-free assays and fluorescence resonance energy transfer (FRET) studies have been used to probe the kinetics of SNARE assembly and disassembly in the presence of the peptide.
Research in neurocosmetics has used Snap-8 as a model compound for studying non-toxin-based modulators of neurotransmitter release at neuromuscular junctions, including ex vivo muscle contraction assays and primary neuron cultures. Structure-activity studies have compared Snap-8 to related SNAP-25 fragments to identify the minimal sequence requirements for SNARE binding activity.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | Snap-8 |
| CAS Number | 868844-74-0 |
| Molecular Formula | C₄₁H₇₀N₁₆O₁₂ |
| Molecular Weight | 975.10 g/mol |
| Sequence / Structure | Ac-EEMQRRAD-NH₂ (8 residues) |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water or PBS |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-022 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Stable at 4°C for 30 days post-reconstitution.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
