Pinealon
A short peptide bioregulator reference standard (Glu-Asp-Arg) originally identified from bovine pineal gland peptide fractions. Used in neuronal cell-model assays examining anti-apoptotic and antioxidant pathway endpoints, circadian biology research, and chromatin-interaction studies in vitro. Developed by the St. Petersburg Institute of Bioregulation and Gerontology. 99%+ purity by HPLC & MS.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
Pinealon (Glu-Asp-Arg) is a synthetic tripeptide bioregulator reference standard originally identified through research on peptide fractions extracted from bovine pineal gland tissue. It was developed by the St. Petersburg Institute of Bioregulation and Gerontology under the direction of V.Kh. Khavinson.
As a short peptide bioregulator, pinealon is studied as a proposed epigenetic modulator: its small size and amphipathic properties allow membrane permeation, enabling chromatin-interaction assays in pineal and neural cell preparations. In vitro studies have used it as a tool compound to characterize antioxidant pathway readouts (ROS scavenging assays) and anti-apoptotic signaling endpoints in neuronal cell lines.
Preclinical model studies have employed pinealon in circadian biology assays examining activity-rest rhythm endpoints, and in mitochondrial function measurements in neural tissue preparations. These represent laboratory model systems; all findings are preclinical and do not constitute evidence of any therapeutic effect.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name | Pinealon |
| CAS Number | N/A |
| Molecular Formula | C₁₃H₂₂N₄O₅ |
| Molecular Weight | 314.3 g/mol |
| Sequence / Structure | Glu-Asp-Arg (tripeptide) |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in sterile water or dilute acetic acid |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-052 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- After reconstitution: stable 14–21 days at 4°C; avoid repeated freeze-thaw.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
