AOD9604
A modified C-terminal fragment of human growth hormone spanning residues 177–191, with Tyr replacing the native Pro at position 177 and stabilized by a disulfide bond. Preclinical models characterize selective lipolytic activity in adipose tissue without measurable IGF-1 stimulation or mitogenic activity.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
AOD9604 (Anti-Obesity Drug 9604) is a modified fragment of human growth hormone (hGH), corresponding to residues 177–191 with a tyrosine substitution at position 177 to improve stability. It was developed as a tool to probe the lipolytic activity attributed to the C-terminal region of hGH, distinct from the receptor-binding domains responsible for growth promotion.
In vitro adipocyte studies have characterized AOD9604's effects on lipolysis (fatty acid and glycerol release), lipogenesis inhibition, and gene expression of lipid metabolism enzymes. Unlike full-length hGH, AOD9604 does not activate the classic GH receptor signaling cascade associated with IGF-1 induction or cell proliferation, making it a useful reagent for studying the independent lipolytic signaling domain.
Rodent model research has examined AOD9604's effects on fat mass, plasma lipid profiles, and energy expenditure in obesity models. Structure-activity studies have used it alongside the native HGH(176-191) fragment to characterize the contribution of the tyrosine modification and disulfide bridge to receptor selectivity and metabolic activity.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | AOD9604 |
| CAS Number | 221231-10-3 |
| Molecular Formula | C₇₈H₁₂₃N₂₃O₂₃S₂ |
| Molecular Weight | 1,815.1 g/mol |
| Sequence / Structure | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (disulfide bond Cys7-Cys15) |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-021 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Reconstituted solution stable 14 days at 4°C.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
