Tesamorelin
A synthetic analogue of endogenous GHRH (44 amino acids) with a trans-3-hexenoic acid modification at the N-terminus for enzymatic stability. Among the most well-characterized GHRH analogues, with an extensive preclinical and clinical research literature. Used in metabolic, adipose, and pituitary axis research models.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
Tesamorelin is a full-length GHRH analogue in which a trans-3-hexenoic acid moiety is conjugated to the N-terminus of the native 44-amino acid GHRH sequence. This modification confers enhanced stability against dipeptidylpeptidase IV (DPP-IV) cleavage compared to unmodified GHRH, extending its pharmacological activity window in preclinical models.
As a full-length GHRH analogue, tesamorelin binds the pituitary GHRH receptor (GHRHR) with high affinity and stimulates GH secretion in a pulsatile, physiological pattern. This pulsatility distinguishes it from CJC-1295 with DAC, which produces more sustained, non-pulsatile GH elevation — making tesamorelin a useful pharmacological comparator for studying GH pulse pattern effects.
Research applications include GH axis characterization, pituitary receptor pharmacology, and metabolic studies in rodent models. It is also studied as a reference compound in visceral adipose tissue research given its well-characterized effects on lipid metabolism in preclinical literature.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | Tesamorelin |
| CAS Number | 218949-48-9 |
| Molecular Formula | C₂₂₁H₃₆₆N₆₈O₆₇S |
| Molecular Weight | 5,135.8 g/mol |
| Sequence / Structure | trans-3-hexenoic acid-GHRH(1-44)-NH₂ (44 residues, N-terminal modified) |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water or 0.1% acetic acid |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-007 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Reconstituted solution stable 14–21 days at 4°C; use bacteriostatic water to extend post-reconstitution stability.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
