Ipamorelin
A selective, pentapeptide growth hormone secretagogue and ghrelin receptor agonist. Among the most selective GHS peptides characterized, with minimal off-target stimulation of cortisol or prolactin in preclinical models. Widely used in pituitary and metabolic research.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) is a synthetic pentapeptide and third-generation GH secretagogue developed to retain potent GHSR-1a agonism while eliminating the off-target stimulation of ACTH, cortisol, and prolactin seen with earlier GH-releasing peptides (GHRP-6 and GHRP-2). This selectivity profile makes it the most widely used reference peptide in ghrelin receptor pharmacology for studies where HPA axis activation is an unwanted confound.
In receptor binding studies, ipamorelin displays high affinity and selectivity for GHSR-1a, producing robust cAMP and IP3 signaling without activating related receptor subtypes. Comparative in vitro studies using pituitary somatotroph preparations have established its position as the benchmark third-generation compound against which novel GHS peptides are evaluated.
Animal model research has characterized ipamorelin's stimulation of pulsatile GH secretion, its synergistic interaction with GHRH analogues (CJC-1295, sermorelin), and the absence of cortisol or prolactin elevation at GH-releasing doses. These properties make it a frequently chosen pharmacological tool for studying the GH axis without concurrent HPA axis activation.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | Ipamorelin |
| CAS Number | 170851-70-4 |
| Molecular Formula | C₃₈H₄₉N₉O₅ |
| Molecular Weight | 711.85 g/mol |
| Sequence / Structure | Aib-His-D-2-Nal-D-Phe-Lys-NH₂ |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water or 0.1% acetic acid |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-005 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Stable at 4°C for up to 30 days after reconstitution.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
