Sermorelin
A synthetic 29-amino acid analogue corresponding to the N-terminal active fragment of endogenous growth hormone-releasing hormone (GHRH). Binds GHRHR on pituitary somatotrophs, stimulating GH secretion. Used extensively in pituitary research and GH axis characterization.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
Sermorelin (GHRH(1-29)-NH₂) is the biologically active N-terminal 29-residue fragment of the 44-amino acid native growth hormone-releasing hormone. It retains full receptor-binding and GH-secretory activity relative to the full-length peptide in preclinical models, making it the standard reference agonist for pituitary GHRH receptor (GHRHR) research.
In vitro studies using somatotroph cell cultures and GHRHR-expressing heterologous systems have characterized sermorelin's receptor binding kinetics, cAMP induction, and GH secretion dose-response relationships. It has been used as a positive control compound in screening assays for novel GHRH analogues.
Animal model research has examined sermorelin's effects on pulsatile GH secretion patterns, IGF-1 production, and somatotroph cell biology. Pharmacokinetic studies have characterized its rapid plasma clearance compared to longer-acting GHRH analogues such as CJC-1295 with DAC, providing a useful pharmacological contrast for mechanism studies.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | Sermorelin |
| CAS Number | 86168-78-7 |
| Molecular Formula | C₁₄₉H₂₄₆N₄₄O₄₂S |
| Molecular Weight | 3,357.9 g/mol |
| Sequence / Structure | GHRH(1-29)-NH₂ · 29 residues |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water or 0.1% acetic acid |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-014 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C (lyophilized). Reconstituted solutions stable 14–21 days at 4°C.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
