GHRP-2
A synthetic hexapeptide and second-generation GH secretagogue acting as a ghrelin receptor agonist. Characterized by high potency at GHSR-1a with moderate stimulation of cortisol and prolactin. Widely used in GH axis, ghrelin biology, and appetite regulation research.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
GHRP-2 (D-Ala-D-β-Nal-Ala-Trp-D-Phe-Lys-NH₂) is a second-generation synthetic GH-releasing peptide that acts as a potent agonist at the growth hormone secretagogue receptor type 1a (GHSR-1a), also known as the ghrelin receptor. It was developed as an improved analogue of the first-generation GHRP-6 with greater potency at GH secretion and reduced food-intake stimulation in animal models.
In vitro work with GHSR-1a-transfected cells has characterized GHRP-2's binding affinity, cAMP and IP3 signaling responses, and receptor internalization kinetics. It is frequently used alongside GHRP-6 and ipamorelin as a reference compound to study structure-activity relationships at the ghrelin receptor.
Animal studies have examined GHRP-2's stimulation of pulsatile GH secretion, its synergistic effects with GHRH analogues (CJC-1295, sermorelin), and its moderate stimulation of ACTH and cortisol release—a property that distinguishes it from the more selective ipamorelin. This makes GHRP-2 useful as a pharmacological tool when studying the ghrelin receptor's broader signaling effects beyond the GH axis.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | GHRP-2 |
| CAS Number | 158861-67-7 |
| Molecular Formula | C₄₅H₅₅N₉O₆ |
| Molecular Weight | 817.99 g/mol |
| Sequence / Structure | D-Ala-D-β-Nal-Ala-Trp-D-Phe-Lys-NH₂ |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-015 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Stable at 4°C for up to 30 days after reconstitution.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
