GHRP-6
The original synthetic hexapeptide GH secretagogue; a ghrelin receptor agonist that dose-dependently stimulates pituitary GH secretion. Notable for concurrent appetite stimulation in animal models, making it a reference compound for ghrelin receptor biology and orexigenic pathway research.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂) was the first synthetic hexapeptide growth hormone-releasing peptide to be extensively characterized. It was discovered in the early 1980s and served as the foundational compound for the ghrelin receptor (GHSR-1a) field, preceding the identification of ghrelin itself as the endogenous ligand.
As the reference first-generation GHRP, GHRP-6 is widely used in comparative receptor pharmacology studies alongside second-generation agents (GHRP-2) and selective secretagogues (ipamorelin) to benchmark receptor binding affinity, cAMP signaling efficiency, and the extent of off-target ACTH/cortisol co-stimulation.
A distinguishing feature of GHRP-6 in animal models is its robust stimulation of appetite and food intake at GH-releasing doses, attributed to ghrelin receptor signaling in hypothalamic circuits. This property has made it a standard research tool for studying the intersection of the ghrelin system with appetite regulation, gastric motility, and energy homeostasis.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | GHRP-6 |
| CAS Number | 87616-84-0 |
| Molecular Formula | C₄₆H₅₆N₁₂O₆ |
| Molecular Weight | 873.01 g/mol |
| Sequence / Structure | His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂ |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water or 0.9% saline |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-016 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Post-reconstitution: stable 14–21 days at 4°C.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
