CJC-1295 (DAC)
A long-acting synthetic analogue of growth hormone-releasing hormone (GHRH), modified with Drug Affinity Complex (DAC) technology for extended albumin binding. Characterized by an extended half-life compared to native GHRH in preclinical models. Commonly studied alongside ghrelin receptor agonists in GH axis research.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
CJC-1295 with DAC (Drug Affinity Complex) is a GHRH analogue conjugated via a maleimidopropionic acid linker that allows reversible covalent binding to serum albumin. This albumin-binding modification extends the compound's effective plasma residence time substantially compared to native GHRH(1-44) and non-DAC analogues in rodent pharmacokinetic models.
In vitro characterization has focused on GHRH receptor binding affinity, cAMP induction in somatotroph cell cultures, and the kinetics of its albumin interaction. Compared to CJC-1295 without DAC, the DAC version exhibits a substantially prolonged functional half-life, creating a distinct pharmacological tool for studying the consequences of sustained GHRH receptor activation.
Animal studies have examined CJC-1295 with DAC in the context of GH pulse pattern modification, IGF-1 elevation, and metabolic effects. It is frequently paired with ghrelin receptor agonists (ipamorelin, GHRP-2) to examine GH axis synergy, as GHRH plus GHS combinations produce GH release greater than either compound alone in preclinical models.
All referenced studies are preclinical or in vitro. Not for human use.
Molecular Information
| Full Name / IUPAC | CJC-1295 (DAC) |
| CAS Number | 863288-34-0 |
| Molecular Formula | C₁₅₂H₂₅₂N₄₂O₄₂S |
| Molecular Weight | 3,647.28 g/mol |
| Sequence / Structure | GHRH(1-29)-Lys(40) with maleimidopropionic acid DAC for albumin binding |
| Appearance | White lyophilized powder |
| Solubility | Soluble in sterile water or 0.1% acetic acid |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-006 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- Store at −20°C. Reconstituted solution stable 14–21 days at 4°C; avoid repeated freeze-thaw.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
