MT-1 (Melanotan I)
A linear analogue of α-melanocyte stimulating hormone (α-MSH). Studied as a melanocortin receptor agonist with higher potency than endogenous α-MSH. Research focuses on melanogenesis, photoprotection models, and MC1R signaling.
Free COA included · Free shipment protection · 99%+ purity by HPLC & MS · Lyophilized powder
Certificate of Analysis — Included Free
Every batch independently tested by U.S.-accredited labs. Lot-matched COA confirms identity, purity ≥99% by HPLC, and safety screening.
Research Overview
MT-1 (Melanotan I, afamelanotide) is a linear synthetic analogue of α-melanocyte stimulating hormone (α-MSH) designed for increased potency and metabolic stability compared to the endogenous 13-amino acid peptide. It incorporates a norleucine substitution at position 4 and a D-phenylalanine at position 7.
MT-1 acts as a non-selective agonist at melanocortin receptors (MC1R through MC5R), with primary research interest in MC1R-mediated melanogenesis. Activation of MC1R in melanocytes drives eumelanin production, the photo-protective brown/black melanin pigment.
Unlike MT-2 (Melanotan II), MT-1 is a linear (non-cyclic) peptide with no reported activity at MC3R/MC4R in relevant doses, making it a more selective research tool for studying photoprotection mechanisms. Research has also examined its anti-inflammatory properties via MC1R signaling in immune cells.
Research framing: Sold for research use only. Not approved for any human therapeutic application.
Molecular Information
| Full Name | MT-1 (Melanotan I) |
| CAS Number | 75921-69-6 |
| Molecular Formula | C₇₈H₁₁₁N₂₁O₁₉ |
| Molecular Weight | 1,646.9 g/mol |
| Sequence / Structure | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂ |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in sterile water or dilute acetic acid |
| Format | Lyophilized (freeze-dried) powder |
| SKU | CL-053 |
Quality & Testing
- Purity: ≥99% by HPLC
- Identity: Confirmed by Mass Spectrometry (LC-MS)
- Heavy Metals: Screened; below detection thresholds
- Endotoxin: Tested per LAL assay
- Lot Tracking: Lot number on every vial matches published COA
- Packaging: Nitrogen-purged, sealed glass vials
Storage & Handling
- Short-term: Room temperature (15–25°C), dry, dark — up to 4 weeks
- Long-term: Refrigerated at 2–8°C — up to 18 months lyophilized
- Extended: −20°C; avoid freeze-thaw cycling
- After reconstitution: stable 14–21 days at 4°C; avoid repeated freeze-thaw.
This compound is supplied for in vitro research and laboratory use only. It is not for human or veterinary use, is not a drug or dietary supplement, and has not been evaluated or approved by the FDA or any regulatory agency for any therapeutic application. Purchasers must be 18 years of age or older and qualified researchers operating in compliance with all applicable local, state, and federal regulations governing research chemicals.
